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Laboratorio di Bioinformatica e

Biologia Sintetica

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Logo UniPVDipartimento di Ingegneria

Industriale e dell'Informazione

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Nicolò Politi


Nome Cognome

Nicolò Politi, PhD

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Born in Voghera (PV), on June 1st, 1986
 

Main affiliation

Dipartimento di Ingegneria Industriale e dell'Informazione

Università degli Studi di Pavia

Via Ferrata 5, I-27100 Pavia, Italy

Other affiliations

Centro di Ingegneria Tissutale

Università degli Studi di Pavia

Via Ferrata 5, I-27100 Pavia, Italy

 

Academic Degree

2014 Ph.D. in Bioengineering and Bioinformatics at the University of Pavia, Italy
Thesis: A synthetic close-loop regulator in Escherichia coli to control the concentration of a signalling molecule: bottom-up design, mathematical modelling and in vivo characterization.
2010 Laurea Specialistica (MS degree) in Biomedical Engineering at the University of Pavia, Italy
Thesis: Progetto e realizzazione di circuiti genetici per la produzione e la purificazione di poteine ricombinanti nel batterio E. coli.
2008

Laurea (BS thesis) in Biomedical Engineering at the University of Pavia, Italy
Thesis: Studio di modelli di mielotossicità in soggetti trattati con farmaci antitumorali.

Appointments

2013 - 2015 Research fellow at the Università degli Studi di Pavia, Pavia, Italy
2010 - 2013 PhD Student in Bioengineering and Bioinformatics at the Università degli Studi di Pavia, Pavia, Italy

Research Interests

My main interests are Synthetic Biology and models of biological systems, with focus on the issue of modularity in assembling new functions in living organisms. In particular, I'm interested in designing and implementing simple and complex tasks through a bottom-up approach, relying on the use of mathematical modelling. Another topic of my work is the study of the impact of noise upon the interconnection of quantitatively characterized modules.

Academic Activities

Other Academic Activities

2011

Co-supervisor of the thesis: "Controllo in anello chiuso in E. coli: modellizzazione matematica di un circuito genetico basato sul quorum sensing" of Tommaso Goggia, Biomedical Engineering Bachelor Degree

International and National Organizations, Awards

2011 - today Member of the Italian Bioinformatics Association
2011 "Gruppo Nazionale di Bioingegneria" (10th edition) award for the Master Thesis
2011 Gold Medal at the iGEM 2011 competition (Vrije Universiteit Amsterdam, Amsterdam, NL) with the UNIPV-Pavia Team
2010 Gold Medal at the iGEM 2010 competition (MIT, Cambridge, MA, USA) with the UNIPV-Pavia Team

Publications

International peer reviewed journals

  • N. Politi, L. Pasotti, S. Zucca, M. Casanova, G. Micoli, M. G. Cusella De Angelis and P. Magni. Half-life measurements of chemical inducers for recombinant gene expression. Journal of Biological Engineering, 8:5, 2014
  • S. Zucca, L. Pasotti, N. Politi, M. G. Cusella De Angelis and P. Magni. A standard vector for the chromosomal integration and characterization of BioBrick™ parts in Escherichia coli. Journal of Biological Engineering, 7(1):1-13, 2013
  • L. Pasotti, N. Politi, S. Zucca, M. G. Cusella De Angelis and P. Magni. Bottom-Up Engineering of Biological Systems through Standard Bricks: A Modularity Study on Basic Parts and Devices. PLoSONE, 7(7):e39407, 2012.

Proceedings of national and international conferences

  • L. Pasotti, S. Zucca, N. Politi, M. Casanova, G. Mazzini, M. G. Cusella De Angelis, P. Magni. Bottom-up design of genetic circuits: characterization and re­-use of biological building blocks to engineer predictable systems. Proceedings of BITS 2014. Rome, IT, February 28-28, 2014, p. 37-38
  • S. Zucca, L. Pasotti, N. Politi, M. Casanova, M. G. Cusella De Angelis, P. Magni. Modelling the effects of promoter and regulator copy number variation on the output of inducible systems in engineered genetic circuits. Proceedings of BITS 2014. Rome, IT, February 28-28, 2014, p. 239-240
  • N. Politi, L. Pasotti, S. Zucca, P. Magni. Studying the effects of cell-to-cell variability on the quantitative behaviour of syntehtic biological networks through stochastic simulations. Proceedings of BITS 2014. Rome, IT, February 28-28, 2014, p. 238
  • N. Politi, S. Zucca, L. Pasotti, M. G. Cusella De Angelis, P. Magni. Modelling and implementation of a negative feedback mechanism in E. coli, Proceedings of Synthetic Biology 6.0. London, UK, July 09-11, 2013, The BioBricks Foundation
  • L. Pasotti, N. Politi, S. Zucca, M. Casanova, M. G. Cusella De Angelis, P. Magni. Interconnection of quantitatively characterized genetic devices to engineer predictable biological functions. Proceedings of Synthetic Biology 6.0, London, UK, July 09-11, 2013, The BioBricks Foundation
  • S. Zucca, L. Pasotti, N. Politi, M. G. Cusella De Angelis, P. Magni. In vivo and in silico approaches to study the effects of copy number variation on gene networks behaviour. Proceedings of Synthetic Biology 6.0, London, UK, July 09-11, 2013, The BioBricks Foundation
  • N. Politi, S. Zucca, L. Pasotti, M. G. Cusella De Angelis and P. Magni, Controlling 3OC6-HSL concentration by a negative feedback-loop genetic circuit in E. coli. Congresso Nazionale di Bioingegneria – Atti. Roma, IT, June 26-29, 2012
  • L. Pasotti, N. Politi, S. Zucca, M. G. Cusella De Angelis and P. Magni. Studio quantitativo di sistemi modello per validare la modularità di componenti in biologia sintetica. Congresso Nazionale di Bioingegneria - Atti. Roma, IT, June 26-29, 2012
  • G. Bertoni, N. Politi, S. Zucca, F. Sampietro, E. Baldini, D. Bianchini, N. Franceschi, V. Ghio, T. Goggia, E. Pasi, D. Sartori, M. G. Cusella De Angelis and P. Magni. CTRL + E.: Signalling is Nothing Without Control. Proceedings of iGEM 2011, Regional Jamboree. Amsterdam, NL, October 1-2, 2011, The iGEM Foundation
  • N. Politi, L. Pasotti, M. G. Cusella De Angelis, P. Magni. Steps Towards the Design of Complex Quorum Sensing Networks Through Standard Biological Parts:Characterization of a Synthetic LuxR-HSL Repressible Promoter. Proceedings of BITS 2011. Pisa, IT, June 20-22, 2011, p. 130-131, PISA:Edizioni Plus
  • N. Politi, L. Pasotti, S. Zucca, M. Stuppia, M. G. Cusella De Angelis, P. Magni. Characterization of a synthetic luxR-HSL repressible promoter for the design of novel activation-repression circuit in E. coli. Proceedings of Synthetic Biology 5.0. Stanford, USA, June 15-17, 2011, The BioBricks Foundation
  • S. Zucca, L. Pasotti, N. Politi, G. Zambianchi, M. G. Cusella De Angelis and P. Magni. Characterization of promoter strength varying the DNA copy number from one to hundreds of copy. Proceedings of Synthetic Biology 5.0. Stanford, USA, June 15-17, 2011, The BioBricks Foundation
  • L. Pasotti, S. Zucca, M. Meroso, G. Zambianchi, N. Politi, M. G. Cusella De Angelis and P. Magni. Engineering E. coli chromosome through BBa_K300000, a BioBrick integrative base vector. Proceedings of Synthetic Biology 5.0. Stanford, USA, June 15-17, 2011, The BioBricks Foundation
  • S. Zucca, L. Pasotti, G. Zambianchi, M. Lupotto, M. Meroso, R. Barini, S. Bisi, N. Politi, A. Ranieri, F. Sampietro, C. Tassorelli, M. Zocco, M. G. Cusella De Angelis and P. Magni. ProteInProgress. Proceedings of iGEM 2010. Boston, USA, November 6-8, 2010, The iGEM Foundation
  • N. Politi, A. Russu, F. Fiorentini, M. Germani, M. Rocchetti, G. De Nicolao, P. Magni (2010). “Modeling Myelosuppression In Patients Treated With Anticancer Drugs”. Congresso Nazionale di Bioingegneria 2010 - Atti - a cura di A. Cappello, T. D’Alessio, M. Knaflitz, F. M. Montevecchi. Pàtron editore

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Last update 10-03-2014