Dipartimento di Ingegneria
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Current Position
Post-doc Researcher, University of Pavia, Italy
Academic Degree
| 2007 | Laurea (BS thesis) in Biomedical Engineering at the University of Pavia, Italy Thesis: Studio della cinetica della SAP marcata con isotopi di iodio in soggetti affetti da amiloiodis. Score: 110 out of 110 cum laude. |
| 2009 | Laurea Specialistica (MS degree) in Biomedical Engineering at the University of Pavia, Italy Thesis: Progetto e realizzazione di un operone etanologenico per il batterio E. coli. Score: 110 out of 110 cum laude. |
| 2013 |
Ph.D. in Bioengineering and Bioinformatics at the University of Pavia, Italy |
Appointments
| 2016-today | Associate of enGenome srl |
| 2015-today | Bioinformatician at Istituto Neurologico Nazionale Fondazione C. Mondino |
| 2013-2015 | Post-doc Researcher |
| 2009-2013 | PhD Student in Bioengineering and Bioinformatics, Laboratory for Biomedical Informatics and Centre for Tissue Engineering, University of Pavia, Italy |
Research Interests
| Synthetic Biology, NGS data analysis, Bioinformatics and Data Mining |
Academic Activities
| 2010 |
Co-supervisor of the thesis: "Valorizzazione di uno scarto dell’industria casearia: studio della crescita di E. coli nel siero del latte" of Giacomo Zambianchi, Biomedical Engineering Master's Degree |
| 2010 |
Co-supervisor of the thesis: "Progetto di un sistema biologico ingegnerizzato per l'attivazione della vitamina D3 in sedute di emodialisi" of Matteo Meroso, Biomedical Engineering Master's Degree |
| 2011 |
Controllo in anello chiuso in E. coli: modellizzazione matematica di un circuito genetico basato sul quorum sensing |
International and National Organizations, Awards
| 2011 - today | Member of the Italian Bioinformatics Association |
| 2011 | Winner of a gold medal at Regional international Genetically Engineered Machine (iGEM) 2011 competition, Amsterdam, NE |
| 2010 | "Gruppo Nazionale di Bioingegneria" (9th edition) award for the Master Thesis |
| 2010 | Winner of a gold medal at international Genetically Engineered Machine (iGEM) 2010 competition, MIT, Cambridge, MA |
| 2009 | Winner of a gold medal at international Genetically Engineered Machine (iGEM) 2009 competition, MIT, Cambridge, MA |
| 2009 | "Best Food or Energy Project" award at international Genetically Engineered Machine (iGEM) 2009 competition, MIT, Cambridge, MA |
Publications
L. Pasotti, S. Zucca, M. Lupotto, M. G. Cusella De Angelis and P. Magni. Characterization of a synthetic bacterial self-destruction device for programmed cell death and for recombinant proteins release. Journal of Biological Engineering 2011, 5:8 (7 June 2011)
S. Zucca, L. Pasotti, G. Mazzini, M. G. Cusella De Angelis, and P. Magni. Characterization of an inducible promoter in different DNA copy number conditions. BMC Bioinformatics, 13(Suppl 4), 2012.
L. Pasotti, N. Politi, S. Zucca, M. G. Cusella De Angelis and P. Magni. Bottom-up engineering of biological systems through standard bricks: a modularity study on basic parts and devices. PLoS One 7(7) 2012.
S. Zucca, L. Pasotti, N. Politi, M. G. Cusella De Angelis, and P. Magni. A standard vector for the chromosomal integration and characterization of BioBricks(TM) parts in Escherichia coli, Journal of Biological Engineering, Journal of Biological Engineering 2013, 7:12 (10 May 2013)
N. Politi, L. Pasotti, S. Zucca, M. Casanova, G. Micoli, M. G. Cusella De Angelis and P. Magni. Half-life measurements of chemical inducers for recombinant gene expression. Journal of Biological Engineering, 8:5, 2014
Massaiu I, Pasotti L, Casanova M, Politi N, Zucca S, Cusella De Angelis MG, Magni P. Quantification of the gene silencing performance of rationally designed synthetic small RNAs. System and Synthetic Biology, 2015
Zucca S, Pasotti L, Politi N, Casanova M, Mazzini G, Cusella De Angelis MG, Magni P. Multi-faceted characterization of a novel LuxR-repressible promoter library for Escherichia coli. PLoS 2015 May 26;10(5):e0126264. doi: 10.1371/journal.pone.0126264.
Pasotti L and Zucca S. "Advances and Computational Tools towards Predictable Design in Biological Engineering." Computational and mathematical methods in medicine 2014 (2014).
Politi N, Pasotti L, Zucca S, Magni P. "Modellingthe effectd of cell-to-cell variability on the output of interconnected networks in bacterial populations" BMC Systems Biology (2015)
Pasotti L, Zucca S, Casanova M, Politi N, Massaiu I, Micoli G, Calvio C, Cusella De Angelis MG, Magni P. "Methods for genetic optimization of biocatalysts for biofuel production from dairy waste through synthetic biology" IEEE-EMBC (2015)
Casanova M, Pasotti L, Zucca S, Politi N, Massaiu I, Calvio C, Cusella De Angelis MG, Magni P. "A BioBrick(TM)-compatible vector for allelic replacement using the xylE gene as selection marker". Biological Procedures Online (2016)
Zucca S, Villaraggia M, Gagliardi S, Grieco G, Valente M, Cereda C, Magni P. "Methodologies for the reliable analysis of amplicon-based NGS data managing allele drop-out effects", BMS Bioinformatics (2016) (accepted after revision)
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