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Laboratorio di Bioinformatica e

Biologia Sintetica

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Logo UniPVDipartimento di Ingegneria

Industriale e dell'Informazione

Percorso

Enrica Mezzalana


Nome Cognome

Enrica Mezzalana, PhD

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Born in Verona (VR), on March 16th, 1985
 

Main affiliation

Dipartimento di Ingegneria Industriale e dell'Informazione

Università degli Studi di Pavia

Via Ferrata 5, I-27100 Pavia, Italy

Academic Degree

2014 Ph.D. in Bioengineering and Bioinformatics at the University of Pavia, Italy
Thesis: A Target Mediated Drug Disposition model for Otelixizumab binding on T lymphocytes.
2010 Laurea Specialistica (MS degree) in Biomedical Engineering at the University of Padova, Italy
Thesis: A Multinomial Mixed-Effect Markov-Chain Model for modeling sleep architecture: model performance and validation. Score: 110 out of 110 cum laude.
2007

Laurea (BS thesis) in Biomedical Engineering at the University of Padova, Italy
Thesis: Scelta dei parametri ottimi nella segmentazione di cellule in immagini di endotelio corneale. Score: 110 out of 110.

Appointments

2013 - 2015 Research fellow at the University of Pavia, Pavia, Italy
2010 - 2013 PhD Student in Bioengineering and Bioinformatics at the University of Pavia, Pavia, Italy

Honorary Appointments

Sep-Dec 2012 PhD Internship Fellow, Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, London, UK
Nov 2009-Jul 2010 MSc Internship Fellow, Clinical Pharmacology Modelling and Simulation, GlaxoSmithKline, Verona, Italy

Research Interests

Non linear Mixed effect models, Pharmacokinetic and Pharmacodyanmic modelling, Markov-Chain models, Target Mediated Drug Disposition, monoclonal antibodies   

Publications

International peer reviewed journals

  • R. Bizzotto, S. Zamuner, E. Mezzalana, G. De Nicolao, R.Gomeni, A. C. Hooker and M.O. Karlsson. Multinomial Logistic Functions in Markov Chain Models of Sleep Architecture: Internal and External Validation and Covariate Analysis. AAPS Journal. Volume 13, Number 3, 445-463, DOI: 10.1208/s12248-011-9287-4

Proceedings of national and international conferences

  • T. Sahota, E. Mezzalana, A. Berges, D. Richards, A. MacDonald, D. Austin, S. Zamuner. Real data comparisons of NONMEM 7.2 estimation methods with parallel processing on target-mediated drug disposition models. PAGE 22 (2013) Abstr 2865 [www.page-meeting.org/?abstract=2865]
  • E. Mezzalana, A. MacDonald,  G. De Nicolao, S. Zamuner. A Target-Mediated Drug Disposition model integrated with a T lymphocyte pharmacodynamic model for Otelixizumab. PAGE 22 (2013) Abstr 2896 [www.page-meeting.org/?abstract=2896]
  • E. Mezzalana, A. MacDonald, R. Bizzotto, G. De Nicolao, S. Zamuner. A Target-Mediated Drug Disposition model to quantify the relationship between Anti-CD3 monoclonal antibody and CD3/TCR receptors in Patients with autoimmune diseases. PAGE 21 (2012) Abstr 2463 [www.page-meeting.org/?abstract=2463]
  • E. Mezzalana, R. Bizzotto, S. Zamuner. Quantitative Assessment of First Night Effect in a Polysomnographic Insomnia Study through a Multinomial Mixed-Effect Markov-Chain Model. PAGE 20 (2011) Abstr 2245 [www.page-meeting.org/?abstract=2245]
  • E. Mezzalana, R. Bizzotto, G. Sparacino, S. Zamuner. Multinomial logistic functions in Markov-chain models for modeling sleep architecture: internal validation based on VPCs. PAGE 19 (2010) Abstr 1893 [www.page-meeting.org/?abstract=1893]

 

Last update 02-03-2014