Mathematical Modelling and

Synthetic Biology Lab


Maria Luisa Sardu

Nome Cognome

Nome Cognome, PhD


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Born in Sassari (SS), on August 11th, 1986

Main affiliation

Dipartimento di Ingegneria Industriale e dell'Informazione

Università degli Studi di Pavia

Via Ferrata 5, I-27100 Pavia, Italy




Academic Degree

2010/2014 Ph.D. in Bioengineering and Bioinformatics at the University of Pavia, Italy.
Thesis: Advanced Model-Based Approaches in Oncological Drug-Development:issues, methods and case studies.
2010/2011 Master Degree in Biomedical Engineering at the University of Pavia, Italy.
Thesis: Modellizzazione dell'inibizione della crescita tumorale e della modulazione di un biomarker associato in esperimenti preclinici in vivo.
2007/2008 Bachelor Degree in Biomedical Engineering at the University of Cagliari, Italy
Thesis: Sistemi di sensing di variabili meccaniche per la misura della postura umana. Score: 104 out of 110.

Research Interests

The main research topics are:(Pharmacokinetics-Pharmacodynamics) PK-PD models in Oncology,both in preclinical and clinical experimental context.Non linear Mixed effects models, drug-driven and biomarker-driven Tumor growth inhibition models. Population PK models to investigate food timing effect in clinical trials.


2014-2015 Post-doc Researcher, University of Pavia, Italy


Honorary Appointments

Dec 2013-May 2014 PhD Intership Fellow, Model Based Drug Develompment,Janssen Pharmaceutica NV, Beerse,Belgium


Proceedings of national and international conferences
  • M.L. Sardu, A. Russu, G. De Nicolao, I. Poggesi. Biomarker-driven models of tumor growth inhibition in preclinical animal studies.PAGE 21 (2012) Abstr 2498 [www.page-meeting.org/?abstract=2498]
  • M.L. Sardu, A. Russu, I. Poggesi, G. De Nicolao. Tumour Growth Inhibition In Preclinical Animal Studies: Steady-State Analysis Of Biomarker-Driven Models.PAGE 22 (2013) Abstr 2880 [www.page-meeting.org/?abstract=2880]
    Last update 30-04-2014