Mathematical Modelling and

Synthetic Biology Lab


Rupesh Kumar Kesharwani

Kesharwani Rupesh Kumar, PhD


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Born in India, on July 22nd, 1987

Main affiliation

Dipartimento di Ingegneria Industriale e dell'Informazione

Università degli Studi di Pavia

Via Ferrata 5, I-27100 Pavia, Italy

Other affiliations

Centro Cardiologico Monzino

Via C. Perea,4-20138, Milano



Current Position

Ph.D., University of Pavia, Italy

Academic Degree

2007 Laurea (BS thesis) in Bachelor  of science at the University of Kanpur, India
2009 Laurea Specialistica (MS degree) in Bioinformatics at the University of Allahabad, India

Ph.D. in Bioengineering and Bioinformatics at the University of Pavia, Italy
Thesis:Role of RAGE in left ventricular function and age-dependent cardiac remodeling: Study of miRNAs, Expression and profiling using next generation approach


25 Mar 10–31 May 11 Research fellow at BBAU University Lucknow, India
1 Jan 12–30 Sep 12 Researcher at CNR, Genova, Italy

Honorary Appointments

2011-12,13 Awarded Italian Govt. scholarship 2011-12 and 2012-13 and worked in CNR –ISMAC, Genoa, Italy

Research Interests

The main research topics are: NGS, small RNA-seq profiling, Drug designing , structural bioinformatics, Modeling, Molecular dynamics etc

Academic Activities


2013 Bioinformatics, UNIPV



 XXXII Scuola Annuale di Bioingegneria, Bressanone, Italy

XXXIII Scuola Annuale di Bioingegneria – 22-25/09/2014,Bressanone, Italy




Gruppo Nazionale Bioingegneria - IV Congresso- Università degli Studi di Pavia

CABgen seminars, CNR, Unipv, Pavia,

27/11/2013   BioLom 2013: 1st Bioinformatics, Computational Biology and System Biology Lombardy Day– Milano

Other Activities

2012 Talk in, International conference and workshop, University o f Bielefeld ,Germany: ‘IntegrativeStructural Bioinformatics system for artificial miRNA(amiRNA) design: an application on CancerResearch’

A bioinformatics workshop organized European Bioinformatics Institute collaboration with University of Pavia, Italy

Participated in BITS2014, Annual Congress of the Italian Society of Bioinformatics, Rome, Italy


1)Saxena S1, Kesharwani RK, Singh V, Singh S. Designing of putative siRNA against geminiviral suppressors of RNAi to develop geminivirus-resistant papaya crop. Int J Bioinform Res Appl. 2013;9(1):3-12. doi: 10.1504/IJBRA. http://www.ncbi.nlm.nih.gov/pubmed/23207994

2) Meraviglia V, Azzimato V, Piacentini L, Chiesa M, Kesharwani RK, Frati C, Capogrossi MC, Gaetano C, Pompilio G, Colombo GI*, Rossini A*.Syngeneic Cardiac and Bone Marrow Stromal Cells display tissue-specific microRNA signatures and microRNA subsets restricted to diverse differentiation processes. PLoS One 2014, DOI: 10.1371/journal.pone.0107269.http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0107269
3) Communicated a research article entitled 'Integrative Structural Bioinformatics approach for synthetic miRNA design: an application to let-7 family' ; j of Mol Mod, 2014
4) Kesharwani RK*, Bono E, Bellazzi R, Colombo GI*. Robust bioinformatics workflow for the comprehensive miRNAs profiling: Next generation sequencing approach. (manuscript in preparation)
5) Kesharwani RK*, Bono E, Bellazzi R, Colombo GI*. Impact of miRNA expression profiling of Zebrafish adult heart exposed to Hypoxia/Rexoygenation cardiac Injaury. (manuscript in preparation).

Last update 2/07/2014