Logo_BMS

 

Lab_name_en

Bioinformatics,

Mathematical Modelling and

Synthetic Biology Lab

Percorso

Lorenzo Pasotti

Lorenzo Pasotti, PhD

Mail:

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Phone:

+39-0382-985366

Born in Voghera (PV), on May 18th, 1984
 

Main affiliation

Department of Electrical, Computer and Biomedical Engineering

University of Pavia

Via Ferrata 5, I-27100 Pavia, Italy

Other affiliations

Centre for Health Technologies (CHT), University of Pavia

Via Ferrata 5, I-27100 Pavia, Italy

 

 

Current Position

Assistant Professor, University of Pavia, Italy

Academic Degree

2012 Ph.D. in Bioengineering and Bioinformatics at the University of Pavia, Italy
Thesis: Quantitative characterization of biological parts and devices for the bottom-up engineering of living systems in synthetic biology.
2008 Laurea Specialistica (MS degree) in Biomedical Engineering at the University of Pavia, Italy
Thesis: Progetto e implementazione di circuiti genetici standardizzati per la realizzazione di funzioni logiche nel batterio E. coli. Score: 110 out of 110 cum laude.
2006

Laurea (BS thesis) in Biomedical Engineering at the University of Pavia, Italy
Thesis: Un approccio per la modellizzazione e l'analisi di dati provenienti da sensori cinestetici indossabili. Score: 110 out of 110.

Appointments

2015-today Assistant Professor (RTDa), Department of Computer, Electrical and Biomedical Engineering, University of Pavia, Italy
2012-2015 Post-doc Researcher, Centre for Tissue Engineering, University of Pavia, Italy
2008-2012 PhD Student in Bioengineering and Bioinformatics, Laboratory for Biomedical Informatics and Centre for Tissue Engineering, University of Pavia, Italy

Honorary Appointments

Jan 2020-today Visiting Researcher, Experimental and Computational Methods for Modeling Cellular Processes (InBio) Group, Department of Computational Biology, Institut Pasteur, Paris, France
Feb-Sep 2011 Visiting researcher, Institute of Structural and Molecular Biology, School of Biological Sciences, University of Edinburgh, Scotland

Research Interests

Synthetic Biology

  • Synthetic circuits in bacteria (design, construction, measurement, modelling, identification and debugging)
  • Predictability of quantitative behaviour of synthetic circuits
  • In vivo control circuits
  • CRISPR interference
  • Quorum Sensing networks

Metabolic Engineering

  • Genome-scale metabolic models
  • Biofuel production from waste with Escherichia coli
  • Polymer production with Bacillus subtilis

PK/PD and PBPK models

  • Nonlinear Mixed-Effect Models
  • Language standardization for modelling & simulation
  • Bayesian models

Bioinformatics

  • Biological networks analysis
  • miRNA regulation

Academic Activities

Courses

2016 - today Bioinformatics (Biotechnology Master's Degree)
2011 - today Bioinformatics and Synthetic Biology (lessons on Synthetic Biology) - Bioengineering Master's Degree

Other Academic Activities

2009 - today Supervisor or co-supervisor of 28 thesis works in the: Bioengineering PhD Program (4), Bioengineering Master's Degree (13), Bioengineering Bachelor's Degree (5), Biological Sciences Bachelor's Degree (1), Molecular Biology and Genetics Master's Degree (2), Biotechnology Master's Degree (3).
2015 - today Reviewer for the Plasmid (Elsevier), Life (MDPI) and PLOS One journals
2016 - today Reviewer for the Italian National Bioengineering Group (GNB) PhD and Master thesis prizes
2019 Member of the Scientific Committee of the 6th International Synthetic & Systems Biology Summer School, Scuola Normale Superiore, July 22-26, Pisa, Italy.
2016 Organization of the 3rd DDMoRe course: Model-informed Drug Development in Oncology (advanced) International School, July 4-8, University of Pavia, Italy.
2015 Invited lecture: “Synthetic Biology”. GRICU PhD National School, September 7th-11th, Padova, Italy. 2015 school name: “Biological and bioprocess engineering”.
2013 Course 20.20 (Instructor: Natalie Kuldell), Introduction to Biological Engineering Design (MIT, Cambridge, USA): seminar on bacterial self-destruction devices
2011 iGEM Judge for the “Food or Energy” and “Manufacturing” area tracks at the European iGEM Jamboree, Amsterdam, The Netherlands
2010 Invited lecture: “BioBrick, Standard Assembly and Registry of Standard Biological Parts”. Italian National Group of Bioengineering XXIX annual school, September 13th-17th, Brixen (TN), Italy. 2010 school name: “Biologia Sintetica”.
2010 and 2011 Course of Cellular and Molecular Bioengineering (Biomedical Engineering, Polo Scientifico-Didattico Cesena, University of Bologna): seminar on quantitative characterization of biological parts in synthetic biology
2009 Course of Bioinformatics (Biomedical Engineering Master's Degree, University of Pavia): seminar on synthetic biology
2008 Dipartimento di Informatica e Sistemistica (University of Pavia): seminar on synthetic biology
2007 Course of Models of Biological Systems (Biomedical Engineering Bachelor's Degree, University of Pavia): seminar on Deconvolution Algorithms

Scientific Activities

International and National Organizations, Awards

2009 - today Member of the IEEE/EMBS
2006 - today Member of the Bioengineering National Group (GNB)
2017 "Best poster" award in the Environmental Sciences and Toxicology session at the XXXV National Conference of Cytometry (organized by the Italian Society of Citometry – GIC), Paestum, Italy, October 3-6.
2012 "Gruppo Nazionale di Bioingegneria" award ("Alberto Mazzoldi" prize, 7th edition) for the PhD Thesis
2010 Winner of a gold medal at international Genetically Engineered Machine (iGEM) 2010 competition, MIT, Cambridge, MA
2009 "Best Food or Energy Project" award at international Genetically Engineered Machine (iGEM) 2009 competition, MIT, Cambridge, MA
2009 Winner of a gold medal at international Genetically Engineered Machine (iGEM) 2009 competition, MIT, Cambridge, MA
2009 "Gruppo Nazionale di Bioingegneria" (9th edition) award for the Master Thesis
2009 Best poster award at ESF European Conference of Synthetic Biology II, Sant Feliu de Guixols, Spain
2008 Fondazione Costa award for the Master Thesis
2008 Winner of a silver medal at international Genetically Engineered Machine (iGEM) 2008 competition, MIT, Cambridge, MA

Publications

Google Scholar publication list

Scopus publication list

Last update 30-8-2019